The expression features and clinical significance of CD4+ CD25+ regulatory T cells in elderly patients with acute myelocytic leukemia
10.3760/cma.j.issn.0254-9026.2013.07.021
- VernacularTitle:老年急性髓细胞白血病患者调节性T细胞的表达及临床意义
- Author:
Huiping WANG
;
Yuanyuan SHEN
;
Shudao XIONG
;
Tianping CHEN
;
Qianshan TAO
;
Rui ZHANG
;
Zhimin ZHAI
- Publication Type:Journal Article
- Keywords:
T-lymphocytes;
Leukemia,myeloid,acute
- From:
Chinese Journal of Geriatrics
2013;32(7):754-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression features and clinical significance of CD4+ CD25+ regulatory T cells in elderly patients with newly diagnosed acute myelocytic leukemia.Methods Totally 65 patients newly diagnosed as acute myeloid leukemia (AML group) and 72 healthy volunteers (control group) were divided into the elderly group (aged over 60 years) and the young group aged (44.6±2.9) years.The expression of CD4+ CD25+ regulatory T cells was detected by CD4,CD25 and CD127 three-color fluorescein-labeled and multiparameter flow cytometry.The expression features and clinical significance of CD4+ CD25+ regulatory T cells in each group were analyzed.Results After being gated on CD4+ lymphocytes,the expression level of CD4+ CD25+regulatory T cells was significantly increased in AML group as compared to control group [(7.06±2.60) ％ vs.(5.61 ± 1.06) ％,t =4.19,P=0.000].The expression level of CD4 + CD25 + regulatory T cells was higher in elderly AML patients than in elderly controls [(7.55 ± 2.78)％ vs.(5.98 ±1.08) ％,t=3.42,P=0.001].The expression of CD4+ CD25+ regulatory T cells was higher in young AML patients than in young controls [(6.09±1.91)％ vs.(5.14±0.82)％,t=2.21,P=0.036].The expression level of CD4+ CD25+ regulatory T cells was higher in elderly AML patients than in young AML patients [(7.55±2.78)％ vs.(6.09±1.91)％,t=2.19,P=0.032].Conclusions The dual roles of immunosenescence and tumor may cause the excessive accumulation of CD4+ CD25+regulatory T cells in elderly patients with newly diagnosed acute myeloid leukemia.
