Follow-up of 5 patients with mycosis fungoides after total skin electron irradiation
10.3760/cma.j.issn.0254-5098.2013.04.016
- VernacularTitle:五例皮肤蕈样霉菌病的全身电子线照射随访结果
- Author:
Li SUN
;
Kangxiong XU
;
Zhenyu ZHAI
;
Jianhua XU
- Publication Type:Journal Article
- Keywords:
Mycosis fungoides;
Total skin electron irradiation;
Follow-up
- From:
Chinese Journal of Radiological Medicine and Protection
2013;33(4):400-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report the total skin electron irradiation(TSEI) to treat the mycosis fungoides and the related acute toxicity,short-term efficacy and long-term results.Methods Five patients with pathologically confirmed mycosis fungoides were enrolled from 1990 to 2011,including 4 males and 1 female.Median age was 51 years old(range 14-56 years old).Dose homegeneity within the field were ± 10％ of the prescribed dose with a skin surface dose of about 90％ of the prescribed dose.Four cases received a total dose of about 30 Gy in 30-32 fractions in 8 weeks,and the other case received an electron boost of 5 Gy to the residual tumor after irradiation with 31 Gy within 31 fractions in 8 weeks,who had received 6 cycles chemotherapy before TSEI.Results 4 cases with a follow-up time of more than 15 years achieved complete response 6 months after radiotherapy.For the recently treated case,a great partial response was achieved after radiotherapy.Acute toxicities for all patients were acceptable.Two patients survived after a follow-up of more than 15 years while the other two cases died of visceral involvement at 1 and 3 years later,respectively.The case treated recently survived 2 months later.Conclusions A total TSEI dose of about 30 Gy within 30-32 fractions during 8 weeks could be proved to be very effective and safe in skin lesion control.Visceral involvement is the main failure type.
