The efficacy of hormone replacement therapy for the treatment of rheumatoid arthritis: a Meta-analysis

VernacularTitle:性激素替代疗法对类风湿关节炎疗效的系统评价
Author: Fan YANG ; Jing PENG ; Yanning ZHAO ; Shaoling YUAN ; Yang LI
Publication Type:Journal Article
Keywords: Eserogen replacement therapy; Arthritis,rheumatoid; Randomized controlled trials; Meta-analysis
From: Chinese Journal of Rheumatology 2013;17(9):606-610
CountryChina
Language:Chinese
Abstract: Objective To explore the efficacy of hormone replacement therapy (HRT) for rheumatoid arthritis (RA).Methods The literature about HRT in the treatment of rheumatoid arthritis were searched.Eleven papers were subjected to a Meta-analysis and a heterogeneity test was conducted to evaluate the efficacy of HRT.Results HRT reduced the level of erythrocyte sedimentation rate (ESR) in RA patients (P=0.016),the SMD was-0.22(-0.40,-0.04); improved bone mineral density (BMD) in RA patients (P=0.022),the WMD was 2.83(0.41,5.26); decreased clinical parameters for disease activity evaluations of RA patients (P=0.048),the SMD was-0.19 (-0.38,0.00); decreased the level of C-reactive protein (CRP) in RA patients,the SMD was-0.08 (-0.37,0.21),but the difference was not statistically significant (P=0.591).Conclusion The findings from this Meta-analysis indicate that HRT can reduce the ESR level,improve clinical indexes and improve BMD level of RA patients.HRT may suppress disease activity and osteoporosis of RA patients,so it may be used as an auxiliary therapy in the treatment of RA.