Risk factors for the presence of hepatic encephalopathy in patients with hepatitis B virus-related acute-on-chronic liver failure in the mid-phase
10.3760/cma.j.issn.1000-6680.2013.07.006
- VernacularTitle:乙型肝炎慢加急性肝功能衰竭中期并发肝性脑病的危险因素分析
- Author:
Minghua LIN
;
Haibing GAO
;
Chen PAN
;
Rui ZHOU
;
Taijie LIN
;
Xiangmei WANG
;
Xiaolou LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Liver failure;
Hepatic encephalopathy;
Risk factors
- From:
Chinese Journal of Infectious Diseases
2013;31(7):404-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for the presence of hepatic encephalopathy in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) in the midphase.Methods A total of 287 patients with HBV-related ACLF in the mid-phase were recruited.Clinical data (age,gender,diabetes,liver cirrhosis,upper gastrointestinal hemorrhage,spontaneous bacterial peritonitis,and pulmonary infection) and laboratory findings [albumin,globulin,total bilirubin (TBil),alanine transaminase (ALT),aspartate aminotransferase (AST),glutamyl transpeptidase (γ-GT),alkaline phosphatase,total cholesterol,cholinesterase,creatinine,prothrombin activity (PTA),international normalized ratio,alpha-fetoprotein (AFP),loads of HBV DNA,serum potassium,serum sodium,white blood cell,and platelet count] were included as potential risk factors and analyzed with univariate and multivariate Logistic regressions.Results Multiple Logistic regression analysis indicated that serum potassium(B =-2.006,P =0.000,OR =0.135,95％CI:0.051-0.353),serum sodium(B=-0.096,P=0.014,OR=0.908,95％CI..0.841-0.981),pulmonary infection (B =1.648,P =0.018,OR =5.199,95 ％ CI:1.326-20.386),AFP (B=-0.010,P =0.024,OR =0.990,95％ CI:0.982-0.999) were correlated with hepatic encephalopathy.Conclusion Hypokalemia,hyponatremia,pulmonary infection and low levels of AFP are independent risk factors of the presence of hepatic encephalopathy in patients with HBV-related ACLF in the mid-phase.
