The antibacterial activity of imipenem in combination with cefoperazone-sulbactam against carbapenem-resistant Acinetobacter baumannii
10.3760/cma.j.issn.1000-6680.2013.07.004
- VernacularTitle:亚胺培南联合头孢哌酮/舒巴坦对耐碳青霉烯鲍曼不动杆菌的抗菌作用
- Author:
Liang YU
;
Mei WANG
- Publication Type:Journal Article
- Keywords:
Imipenem;
Cefoperazone;
Sulbactam;
Acinetobacter baumannii
- From:
Chinese Journal of Infectious Diseases
2013;31(7):396-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the interaction of in vitro antibacterial activity between cefoperazone-sulbactam and imipenem against carbapenem-resistant Acinetobacterbaumannii.Methods The minimum inhibitory concentrations (MIC) of imipenem and cefoperazone-sulbactam against Acinetobacter baumannii were detected and the fractional inhibitory concentration (FIC) index of imipenem/cefoperazone-sulbactam combination was calculated by broth micro-dilution method.The interactions of imipenem and cefoperazone-sulbactam were assayed by K-B agar plate method.Results The MIC50 of cefoperazone-sulbactam and imipenem were both 16 mg/L,and MIC90 of the two drugs were both 64 mg/L.Among the 26 strains of Acinetobacter baumannii,16 strains had FIC indexes ≤0.5,and 10 had FIC indexes≥2.0.K-B agar plate assay showed that the cefoperazone-sulbactam/imipenem combination was synergistic for strains with FIC indexes≤0.5,and antagonistic for strains with FIC indexes ≥ 2.0.Conclusions Imipenem in combination with cefoperazone-sulbactam can be either antagonistic or synergistic against carbapenem-resistant Acinetobacter baumannii.The clinical use of cefoperazone-sulbactam/imipenem combination for the treatment of carbapenem resistance Acinetobacter baumannii infections should be cautious in case of antagonism.
