Local application of NK1 receptor antagonists and pulpal blood flow in cat.
10.5395/JKACD.2004.29.3.239
- Author:
Young Kyung KIM
1
;
Wan Sik CHU
;
Ho Jeong LEE
;
Dong Kuk AHN
;
Hyun Mi YOO
;
Sung Kyo KIM
Author Information
1. Department of Conservative Dentistry, School of Dentistry, Kyungpook National University, Korea. skykim@knu.ac.kr
- Publication Type:Original Article
- Keywords:
NK1 receptor antagonists;
SP;
Pulpal blood flow;
Iontophoresis;
Pulpal inflammation;
Neurogenic inflammation
- MeSH:
Animals;
Arteries;
Blood Pressure;
Catheters;
Cats*;
Chloralose;
Cuspid;
Dental Pulp;
Dentin;
Inflammation;
Iontophoresis;
Neurogenic Inflammation;
Substance P;
Tooth;
Urethane;
Vasodilation
- From:Journal of Korean Academy of Conservative Dentistry
2004;29(3):239-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to investigate the influence of NK1 receptor antagonists on the pulpal blood flow (PBF) when applied iontophoretically through the dentinal cavity of the teeth in order to understand whether iontophoretically applied NK1 receptor antagonists can control the pulpal inflammation. Eleven cats were anesthetized with alpha-chloralose and urethane, and substance P (SP) was administered to the dental pulp through the catheterized lingual artery in doses that caused PBF change without the influence of systemic blood pressure. NK1 receptor antagonists were applied iontophoretically to the prepared dentinal cavity of ipsilateral canine teeth of the drug administration, and PBF was monitored. Data were analyzed statistically with paired t-test. PBF increase after iontophoretic application of the NK1 receptor antagonists followed by the intra-arterial administration of SP was significantly less than PBF increase after iontophoretic application of the 0.9% saline followed by the intra-arterial administration of SP as a control (p < 0.05). Iontophoretic application of the NK1 receptor antagonists (0.2~3.4 mM) following the intra-arterial administration of SP resulted in less increase of PBF than the iontophoretic application of the 0.9% saline following the intra-arterial administration of SP as a control (p < 0.05). Therefore, the results of the present study provide evidences that the iontophoretic application is an effective method to deliver drugs to the dental pulp, and that iontophoretically applied NK1 receptor antagonists block SP-induced vasodilation effectively. The above results show the possibility that the iontophoretical application of NK1 receptor antagonists can control the neurogenic inflammation in the dental pulp.
