The influece of probucol on hs-CRP and BMP-7 in serum of patients with diabetic nephropathy
10.3760/cma.j.issn.1008-6706.2013.22.033
- VernacularTitle:普罗布考对糖尿病肾病患者血清超敏C反应蛋白和骨形态发生蛋白-7的影响
- Author:
Yu ZHU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Probucol;
C-reactive protein;
Bone morphogenetic proteins
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(22):3434-3436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influece of probucol on high-sensitivity C-reactive protein(hs-CRP) and bone morphogenetic protein-7 (BMP-7) in serum of patients with diabetic nephropathy.Methods 124 patients with diabetic nephropathy were randomly divided into two groups,the control group (n =62 cases) and the observation group(n =62 cases).The patients of the control group were treated through the conventional treatment.However,the patients of the observation group were treated by probucol on the basis of conventional treatment.They were treated for eight weeks.The 24-hour urinary protein,hs-CRP and BMP-7 were detected before and after treatment.Results The 24-hour urinary proteins were decreased in both two groups after treatment (t =6.161,5.23,P ＜ 0.01).There was significant difference between two groups(t =5.35,P ＜ 0.05).The hs-CRP and BMP-7 were improved after treatment (t =10.50,5.54,all P ＜ 0.05),while those of the observation group were more significantly improved than those of the control group(t =10.28,4.36,all P＜0.05).Conclusion Probucol could improve the conditions of diabetic nephropathy which was through improving hs-CRP and BMP-7.
