Clinical application of combined detection of serum tumor markers in diagnosis of lung cancer
10.3760/cma.j.issn.1008-6706.2013.18.022
- VernacularTitle:血清肿瘤标志物联合检测在肺癌诊断中的临床应用
- Author:
Jing ZHANG
;
Jimin JIA
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Diagnosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(18):2775-2776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of combined detection of serum tumor markers in the diagnosis of lung cancer,and to select the most sensitive serum tumor markers.Methods Enzyme-linked immunosorbent assay was used to detect the serum tumor markers of 62 lung cancer patients and 62 healthy persons,who were neuron specific enolase enzyme (NES),carbohydrate antigen 125 (CA 125),cytokeratin 19 (CYFRA21-1) and carcinoembryonic antigen(CEA).Results The level of serum CEA,CA125,CYFRA21-1,and NES of the lung cancer group were all higher than those of the control group (all P ＜ 0.05).Among the four kinds of tumor markers,CA125 had the highest sensitivity(59.7％),which was followed by CEA(53.2％).The sensitivity of the four kinds of joint detection was 87.1％,the highest sensitivity of three markers joint detection was CEA + CA125 + CYFRA21-1 (87.1％),while that of the two kinds of joint detection was CEA + CA125 (75.8％).Conclusion There are high clinical significance in the diagnosis of lung cancer with four kinds of serum tumor markers,CEA + CA125 + CYFRA21-1 can be used as the best markers for joint detection of lung cancer with high sensitivity.
