The clinical effects of methylprednisolone pulse therapy on the acute treatment of multiple sclerosis
10.3760/cma.j.issn.1008-6706.2013.19.022
- VernacularTitle:甲泼尼龙冲击治疗急性期多发性硬化症疗效观察
- Author:
Yuzhen ZHANG
;
Yunliang WANG
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Methylprednisolone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(19):2929-2930
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of methylprednisolone pulse therapy on the acute treatment of multiple sclerosis.Methods 46 cases of the acute phase of patients with multiple sclerosis treatment in the hospital's department of neurology were chosen,who were divided in accordance with the principle of randomized controlled study group and the control group,each group of 23 patients.The study group was given methylprednisolone in the treatment and control group were given dexamethasone treatment.The clinical efficacy and complications of the treatment of patients were compared.Results The study group markedly in 14 cases,effective 54 cases,the total effective rate was 82.6％ ;the control group,10 casesmarkedly effective in 4 cases,9 cases ineffective,the total effective rate was 60.9％ ; compared the two sets of data decline before treatment,there was a statistically significant difference (x2 =5.236,P ＜ 0.05).After the treatment,the two groups of patients with EDSS scores compared with EDSS scores of the study group was significantly lower than that of the control group,the difference was statistically significant(t =3.135,P ＜ 0.05).Conclusion In acute phase of patients with multiple sclerosis,methytprednisolone pulse therapy can reduce the incidence of complications,and reduce the patient's nervous system damage,which can improve the quality of life in patients.
