The effects of exenatide on insulin sensitivity in type 2 diabetics patients
10.3760/cma.j.issn.1008-6706.2013.19.020
- VernacularTitle:艾塞那肽对2型糖尿病患者胰岛素敏感性的影响
- Author:
Yan LI
;
Xianxiang ZHANG
;
Yong LUO
;
Bangqiong WANG
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Exenatide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(19):2924-2926
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of exenatide on insulin sensitivity in type 2 diabetics.Methods 42 diabetics of secondary failure of sulfonylurea were recruited in the study,and were distinguished to the exenatide group and the glargine group.Besides being treated with diabetic conventional and original treatments,the two groups were given respectively exenatide before breakfast and dinner,or glargine before sleeping by subcutaneous injection for five weeks.Insulin sensitivity of the two groups was elevated by euglycemic-hyperinsulinemic clamps before and after treatment.The metabolic indices were determined.Results Compared with baseline levels,after treatment the glucose metabolic rate was improved [(5.12 ± 0.35) vs (2.94 ± 0.41)] mg · kg-1 · min-1,P ＜ 0.05],the BMI and HMOA-IR was reduced[4.51 (1.32 ～ 6.12) vs 1.96 (1.32 ～ 6.12)],in the exenatide groups,which were better than the glargine group (P ＜ 0.05).Gastrointestinal adverse reactions,which were tolerable and decreased,were appeared in nearly 31.42％ of subjects.There were no severe hypoglycemic events in both groups.Conclusion Short-term treatment with exenatide could improve the insulin sensitivity of type 2 diabetics.
