The expression and clinical significance of folate receptor in the tissues of primary hepatocellular carcinoma

VernacularTitle:叶酸受体在原发性肝癌组织中的表达及其意义
Author: Peng CHEN ; Lihua HU ; Jiye ZHANG
Publication Type:Journal Article
Keywords: Folate,receptor; Liver neoplasms
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(22):3373-3374
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of folate receptor(FR) in primary hepatocellular carci noma and to explore its correlation with clinical and pathological features.Methods Immunohistochemistry was used to detect the expression of FR alpha and beta in primary hepatocellular carcinoma (45 cases),cirrhosis (32 cases) and normal liver tissue (20 cases).And then the relationship between the expression of FR alpha and clinic0pathological features was analyzed.Results The positive expression of FR alpha was detected in 88.9％ (40/45) primary hepatocellular carcinoma,18.8％ (6/32) cirrhosis,and there was no positive expression of FR alpha in normal liver tissue.There was no FR beta expression in primary hepatocellular carcinoma and cirrhosis,only 15％ (3/20) normal liver tissue expressed FR beta.The expression of FR alpha did not correlate with gender and age,but the positive expression of early-mid-term patients was higher than that of the advanced patients.Conclusion FR alpha is presented in most liver tissues of primary hepatocellular carcinoma,which provide basis of early diagnosis and molecular drug target.