The impact of simvastatin combined with trimetazidine on cardiac function and high-sensitivity C-reactive protein in patients with chronic heart failure
10.3760/cma.j.issn.1008-6706.2013.20.032
- VernacularTitle:辛伐他汀联合曲美他嗪对慢性心力衰竭患者心功能及高敏C反应蛋白的影响
- Author:
Jian DU
;
Wenbin GAO
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Simvastatin;
Trimetazidine;
C-reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(20):3116-3118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of simvastatin combined with trimetazidine on cardiac function and high-sensitivity C-reactive protein(hs-CRP) in patients with chronic heart failure.Methods 160 patients with chronic heart failure were divided into control group and the observation group according to the random number table.The control group was treated with diuretics,inotropic,vasodilators and other conventional treatment,on the basis of this,the observation group received simvastatin combined with trimetazidine treatment.The cardiac function and hs-CRP of the patients were observed,and the treatment effects were evaluated and analyzed.Results The total effective rate of the observation group was 82.50％,which was significandy higher than 52.50％ of the control group (x2 =16.4103,P ＜ 0.001).Compared with before treatment,IL-6,TNF-alpha and hs-CRP levels of two groups after treatment were significantly decreased (t =12.234,13.342,5.463,8.533,7.896,3.536,all P ＜ 0.05),and those in the observation group were significantly lower than the control group (t =4.653,3.976,3.674,all P ＜ 0.05).Conclusion Simvastatin combined with trimetazidine has good effect on the cardiac function of patients with chronic heart failure,and can effectively reduce the level of hs-CRP,it is worthy of clinical application.
