Lamivudine in the treatment of 49 pulmonary tuberculosis patients with chronic hepatitis B

VernacularTitle:拉米夫定治疗肺结核合并慢性乙型肝炎49例
Author: Kun LU
Publication Type:Journal Article
Keywords: Lamivudine; Tuberculosis,pulmonary; Hepatitis B,chronic; Treatment outcome
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(20):3083-3084
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical efficacy of lamivudine in the treatment of pulmonary tuberculosis patients with chronic hepatitis B.Methods 98 pulmonary tuberculosis patients with chronic hepatitis B were divided into two groups.49 patients in the control group were given conventional treatment,and 49 patients in the observation group received lamivudine on the basis of conventional treatment.The clinical efficacy and adverse reactions of two groups were compared.Results During treatment,the liver dysfunction rate of the observation group was 10.20％,which was significantly lower than 18.37％ of the control group(x2 =4.21,P ＜ 0.05).After treatment,the relevant indicators of liver function and HBV-DNA in the observation group were significantly lower than those in the control group(t =10.72,10.11,7.68,all P＜0.05).Conclusion Lamivudine in the treatment of pulmonary tuberculosis patients with chronic hepatitis B has significant effect,which is beneficial to the patients' early recovery,and it is worthy of extensive promotion and application.