Effect of venlafaxine sustained-release tablet combined with Shuganjieyu capsule in the treatment of post-stroke depression
10.3760/cma.j.issn.1008-6706.2013.20.014
- VernacularTitle:文拉法辛联合疏肝解郁胶囊治疗脑卒中后抑郁疗效观察
- Author:
Yong ZHANG
;
Bin XU
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Cerebrovascular accident;
Venlafaxine;
Shuganjieyu capsule
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(20):3074-3076
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect and safety of venlafaxine sustained-release tablet combined with Shuganjieyu capsule and venlafaxine sustained-release tablet used singlely in the treatment of moderate to severe poststroke depression.Methods 70 patients suffered from moderate to severe post-stroke depression were randomly divided into two groups,35 cases in each group.The patients in the control group were only treated with venlafaxine sustained-release tablet,and the patients in the study group were treated by venlafaxine sustained-release tablet combined with Shuganjieyu capsule.The treatment lasted 6 weeks.The therapeutic effect and safety were evaluated by the positive and negative syndrome scale of HAMD (17 items),and treatment emergent symptom scale of TESS.Results After treatment for 6 weeks,the total effective rate of the study group was 88.57％,which was significantly higher than 65.71％ of the control group (x2 =5.19,P ＜ 0.05).The HAM D score of the study group w.as (16.42 ± 6.07) points,and the HAMD score of the control group was(10.54 ± 5.23) points after 6 weeks.The difference was statistically significant between the two groups (t =4.34,P ＜ 0.01).The difference of TESS score between two groups was not significant(t =0.18,P ＞ 0.05).Conclusion Venlafaxine sustained-release tablet combined with Shuganjieyu capsule is effective and safe in the treatment of moderate to severe post-stroke depression.
