Observation on the effect of azithromycin in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its influence on the serum inflammatory cytokines level of patients
10.3760/cma.j.issn.1008-6706.2013.18.029
- VernacularTitle:阿奇霉素治疗慢性阻塞性肺疾病急性加重期的疗效观察及对患者血清炎性因子水平的影响
- Author:
Zhongbo LU
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Azithromycin;
InterleukinTumor necrosis factor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(18):2791-2793
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of azithromycin in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and its influence on the serum interleukin-10(IL-10),intedeukin-8 (IL-8)and tumor necrosis factor-αt (TNF-a) level of patients.Methods According to the digital table,92 patients with AECOPD were divided into the control group and the observation group,each group 46 cases.The control group was given conventional therapy,and the observation group was given azithromycin on the basis of the treatment of the control group,and the treatment lasted one week.The effect and the change of the serum IL-I0,IL-8 and TNF-α level were compared between the two groups.Results The total effective rate of the observation group was 91.3％,which was significantly higher than that of the control group(χ2 =8.165,P ＜ 0.05).After treatment,there was no statistically significant difference in the serum IL-8 and TNF-α level between the two groups (t =0.655,0.447,all P ＞ 0.05),but the serum IL-10 level of the observation group was (15.71 ± 2.88)pg/L,which was significantly higher than that of the control group[(12.59 ± 1.12) pg/L] (t =6.848,P ＜ 0.01).Conclusion Azithromycin in the treatment of AECOPD has definite effect,and can adjust the immune system of patients to release the inflammatory inhibitors and inhibit airway inflammation.
