Efficacy evaluation of aztreonam in combination with cefepime for the treatment of urinary tract infectious

VernacularTitle:氨曲南联合头孢吡肟治疗泌尿系统感染疗效分析
Author: Luping SONG
Publication Type:Journal Article
Keywords: Urinary tract infections; Aztreonam; Cefepime
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(19):2967-2969
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical efficacy of aztreonam in combination with cefepime for the treatment of urinary tract infections.Methods A randomized block grouping,123 cases of urinary tract infections were divided into observation group,aztreonam group and cefepime group,41 cases in each group.The observation group was treated with aztreonam (2.0g) and cefepime (2.0g),control group were given aztreonam and cefepime,respectively.The treatment time lasted 7 days.Results The total effective rate of observation group was 95.1％,compared with cefepime(85.4％)or aztreonam(82.9％) group,the difference was statistically significant(x2 =12.89、13.56,all P ＜ 0.05).After the end of treatment,the observation group bacterial clearance rate (94.3％) was slightly higher than that of cefepime group or aztreonam group.Each group had only minor adverse reaction,which did't affect the continued medication.And the difference in the incidence was not statistically significant(P ＞0.05).Conclusion Cefepime joint aztreonam in the treatment of urinary tract infection can improve the therapeutic efficacy,and adverse events doesn't increase.