Analysis of the efficacy and security of entecavir combined with interferon sequential therapy in the treatment of chronic hepatitis B

VernacularTitle:恩替卡韦联合干扰素序贯治疗慢性乙型肝炎的疗效及安全性分析
Author: Jingrong CUI ; Cuiling ZHENG ; Aiqing LIU
Publication Type:Journal Article
Keywords: Entecavir; Interferon; Drug therapy,combination; Hepatitis B,chronic
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(17):2616-2618
CountryChina
Language:Chinese
Abstract: Objective To discuss the efficacy and security of entecavir and interferon sequential combination therapy on chronic hepatitis B.Methods 108 patients with chronic hepatitis B were randomly divided into the sequential combination therapy group,the entecavir group and the interferon group.Each group had 36 cases.The efficacy and security of different therapy were observed.Results The HBV DNA negative rate of the sequential combination therapy group was 77.78％,and the ALT normalization rate was 91.67％,which were both higher than those of the entecavir group and the interferon group(x2 =14.40,22.12,20.07,18.47,all P ＜ 0.05).The total effective rate of the sequential combination therapy group was 91.67％,which was obviously higher than that of entecavir group and the interferon group(x2 =12.09,6.82,all P ＜ 0.05).The entecavir and interferon sequential combination therapy had a good security.Conclusion Entecavir combined with interferon sequential therapy in the treatment of chronic hepatitis B had a significant clinical efficacy and deserved promotion.