Study on the enhancement effect of N-trimethyl chitosan on transdermal absorption of 8-methoxypsoralenloaded liposomal gels in vitro

VernacularTitle:N-三甲基壳聚糖对甲氧沙林脂质体凝胶的透皮吸收促进作用研究
Author: Shuhai YU ; Xianxi GUO ; Wen HE
Publication Type:Journal Article
Keywords: N-trimethyl chitosan; 8-methoxypsoralen-loaded liposomal gels; Transdermal enhancement
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(17):2587-2589
CountryChina
Language:Chinese
Abstract: Objective To explore the enhancement effect of N-trimethyl chitosan(TMC) on transdermal absorption of 8-methoxypsoralen-loaded liposomal(LMOP) gels in vitro.Methods TMC with quaternization degree of 60％ (TMC60) as the enhancer,the LMOP gels were prepared with free TMC60 or TMC60-coating.The enhancement of free TMC60 or TMC60-coating was studied by using Franz diffusion,cells with LMOP gels as the negative control and LMOP gels including 1％ Azone + propylene glycol as the positive control.Results Compared with the negative control,enhancement and drug amount in skin of LMOP gels with enhancer all showed significant difference (x2 =8.65,P ＜ 0.05),and the free TMC.60 was the best.Conclusion TMC can enhance the transdermal penetration of LMOP gels in vitro and is valuable to be studied further.