Influence of olanzapine combined with risperidone on the serum level of homocysteine in patients with schizophrenia

VernacularTitle:奥氮平联合利培酮对精神分裂症患者血清同型半胱氨酸水平的影响
Author: Zhiguang DU ; Xinguo TAN ; Cunqiang LIU
Publication Type:Journal Article
Keywords: Olanzapine; Risperdal; Schizophrenia; Homocysteine
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(17):2574-2576
CountryChina
Language:Chinese
Abstract: Objective To explore the influence of olanzapine combined with risperidone on the serum level of homocysteine (Hcy) in patients with schizophrenia.Methods Participants included sixty patients diagnosed with schizophrenia,patients were divided into two groups by means of random digital method.The group A was given olanzapine treatment,and the B group was given olanzapine combined with risperidone therapy.After two months follow-up,the curative effect and the level of Hcy were observed.Results Before treatment,Hcy level [(24.4 ± 6.1)μmol/L,(25.8 ± 7.7)μmol/L] and HH number (22 cases,23 cases) in the two groups had no obvious differences (t =1.11,x2 =1.34,all P ＞ 0.05) ;2 months after treatment,Hcy level (11.6 ± 8.6) μmol/L and HH number(16 cases) in group B were significantly lower than those in the group A [(16.3 ± 3.8) μmol/L,8 cases],the differences were statistically significant (t =4.65,x2 =4.32,all P ＜ 0.05).Conclusion Olanzapine combined with risperidone in treatment of schizophrenia have good curative effect,it can improve the symptoms of patients,decrease serum Hcy level and HH number.