Observation on the effect of Alpha-Lipoic acid combined with Monosialotetrahexosylganglioside in the treatment of diabetic peripheral neuropathy
10.3760/cma.j.issn.1008-6706.2013.18.011
- VernacularTitle:α-硫辛酸联合神经节苷脂治疗糖尿病周围神经病变的疗效观察
- Author:
Changming LUO
- Publication Type:Journal Article
- Keywords:
Diabetic neuropathies;
Alpha-Lipoic acid;
Monosialotetrahexosylganglioside
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(18):2747-2749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effect of alpha-lipoic acid(ALA) combined with monosialotetrahexosylganglioside(GM1) in the treatment of diabetic peripheral neuropathy (DPN).Methods According to random number table,98 type 2 diabetic patients with DPN were divided into the control group and treatment group according to the principle of informed consent,each group 49 cases.The control group was treated with ALA 600mg/d by intravenous drip infusion once a day for 3 weeks.The treatment group was treated with ALA 600mg/d and GM1 60mg by intravenous drip infusion once a day for 3 weeks.The changes of nerve system symptoms and signs were observed before and after treatment,measurement of nerve conduction velocity (NCV) and fasting blood glucose,examination of knee tendon and Achilles tendon reflex,blood and urine routine and hepatic and renal function.Results The total effective rate of treatment group was 91.84％,which was higher than that of the control group (67.35 ％) (χ2 =52.01,P ＜ 0.05).After the treatment,the motor nerve conduction velocity (MNCV),sensory nerve conduction velocity(SNCV) of the treatment group increased significantly higher than those of the control group(t =1.987,1.972,1.972,1.972,all P＜0.05).Conclusion ALA combined with GM1 in the treatment of DPN is safe and effective.
