Utility of whole-body diffusion-weighted imaging in the detection of bone metastases in malignant tumors
10.3760/cma.j.issn.1006-9801.2013.03.013
- VernacularTitle:全身弥散加权成像在恶性肿瘤骨转移诊断中的应用
- Author:
Yan ZHANG
;
Xixing WANG
;
Jun WANG
;
Yongbo HUANG
;
Jianxin ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Diffusion magnetic resonance imaging;
Neoplasms metastasis
- From:
Cancer Research and Clinic
2013;(3):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application of whole-body diffusion-weighted imaging (WB-DWI),and to detect bone metastasis in malignant tumor patients.Methods A total of 118 malignant tumor patients prospectively underwent WB-DWI,standard MRI/CT in suspicious bone metastases parts within one week after inspection.Final diagnosis of the bone metastases in each patient was determined on the basis of results of all radiologic and follow-up examinations.The differential diagnosis value of apparent diffusion coefficient (ADC) in benign and malignant bone metastases was compared with the variance analysis.Results Area under ROC curve value of WB-DWI with standard MRI/CT (0.999) was larger than that of WB-DWI (0.944) and standard MRI/CT (0.983),and the specificity,accuracy and positive predictive value were also the highest(100.0 ％,97.4 ％,100.0 ％).The ADC values of malignant bone metastases were significantly lower than those of benign lesions[(0.71±0.15)×10-3 mmTs vs (1.50±0.23)×10-3 mm2/s] with a statistically significant difference(F =261.587,P ＜ 0.001).Conclusion WB-DWI is the beneficial supplements of standard MRI/CT.Which can be used for assessment and differential diagnosis of bone metastases in malignant tumor patients combined with ADC value.
