Effects of AKT phosphorylation in lymphangiogenesis and lymphatic metastasis of breast cancer
10.3760/cma.j.issn.1006-9801.2013.06.023
- VernacularTitle:AKT磷酸化在乳腺癌淋巴管生成及转移中的作用
- Author:
Xiaofang HU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Lymphangiogenesis;
Lymphatic metastasis;
AKT
- From:
Cancer Research and Clinic
2013;(6):426-428
- CountryChina
- Language:Chinese
-
Abstract:
Lymphatic metastasis in breast cancer is the most frequent route of metastasis,which is one of most pirotal factors generated comparatively earlier in determining breast cancer staging and electing therapeutic regimen.Lymphangiogenesis is the foundation of lymphatic metastasis.The PI3K/AKT/VEGF-C signal transduction pathway may exist in breast cancer lymphangiogenesis,in which AKT phosphorylation promotes breast cancer lymphangiogenesis and lymphatic metastasis.This article mainly reviews the adjusted effects of AKT phosphorylation in breast cancer lymphatic metastasis.
