Prognostic analysis of radiotherapy and chemoradiotherapy in patients with esophageal cancer
10.3760/cma.j.issn.1006-9801.2013.06.005
- VernacularTitle:食管癌患者单纯放疗与同期放化疗的预后分析
- Author:
Xin SONG
;
Hui SONG
;
Hongwei LI
- Publication Type:Journal Article
- Keywords:
Esophogeal neoplasms;
Radiothrapy,computer-asslsted;
Drug therapy;
Prognosis
- From:
Cancer Research and Clinic
2013;(6):378-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare prognosis of esophageal cancer patients with simple radiation or chemoradiotherapy.Methods Retrospective analysis 266 cases of esophageal cancer patients from June 2005 to June 2007 of,including 128 with simple radiotherapy,138 with chemotherapy during the same period,157 cases of general radiotherapy,intensity-modulated radiotherapy,109 cases of Kaplan-Meier method for calculation of survival,Log-Rank method on the clinical factors of single factor analysis,Cox regression model with factor analysis.Two groups,clinical material and adverse reaction were compared with chi-square test.Results The median survival time of the radiation group was 25 months,chemoradiotherapy group of the median survival time was 28 months.Follow-up with 1,3,5 years were 231,106,82 cases.The 1,3,4 years OS rate were 86.8 ％ (200/231),12.8 ％ (14/106),9.0 ％ (7/82).Disease-free survival (DFS) rates were 39.8 ％ (92/231),7.9 ％ (8/106),15.8 ％ (13/82).No local relapse survival (LRFS) rates were 30.8 ％ (71/231),16.2 ％ (17/106),23.7 ％ (19/82).No distant metastasis (DMFS) survival rates were 47.0 ％ (109/231),11.3 ％ (12/106),13.9 ％ (11/82).Single factor analysis results show that age,disease length,X-ray parting,different radiation method were 5 years OS independent prognostic factors.Age,disease length were DFS independent prognostic factors.Lesion length,different radiation method were LRFS independent prognostic factors for survival,lesion length and X-ray parting were without distant metastases independent prognostic factors for survival.Multiple factors analysis results showed that age,disease length,pathological type were 5 years OS related factors,and age,disease length,different treatment methods were DFS related factors,only lesions length was DMFS related factors,lesion length,different chemotherapy method was DMFS related factors of survival.The rate of serious adverse reaction of the chemoradiotherapy group was higher than radiotherapy group,the difference had statistical significance.Conclusion The chemoradiotherapy increase DFS rate,and at the same time,the incidence of adverse reaction also increases,but 5 years OS rate doesn't increased obviously.
