Treatment of scar contracture with intralesional botulinum toxin type A injection

VernacularTitle:A型肉毒毒素治疗挛缩性瘢痕
Author: Tongtong YAN ; Minliang CHEN ; Kui MA ; Liming LIANG ; Chang LIU ; Linying LAI ; Xiaobing FU
Publication Type:Journal Article
Keywords: Scars contracture; Botulinum toxin type A (BTXA); α-smooth muscle actin (α-SMA); Myosin-Ⅱ
From: Chinese Journal of Medical Aesthetics and Cosmetology 2013;(3):196-199
CountryChina
Language:Chinese
Abstract: Objective To evaluate the validity of botulinum toxin type A (BTXA) injections for the treatment of scar contracture.Methods 26 patients with scar contracture were randomly assigned into BTXA group and triamcinolone acetonide (TAC) group.Pinpoint tattooing was performed on each side of each scar in the plane of its longest axis.A template was used to ensure consistent length.These two tattoo points were measured to assess scar contraction at baseline,at every month for a total of 6 months.Histological analysis was conducted to study the physiological environment and immunohistochemistry to detect the expression of α-SMA and myosin-Ⅱ at different groups.Results Scar contraction was more relaxed in BTXA group than that in TAC group after 1 month (P＜0.05),especially in the 6th month (the D value in BTXA group and TAC group was (1.23±0.42) cm,and (0.56±0.33) cm respectively).For immunohistochemistry,the expression of α-SMA and myosin-Ⅱ also decreased in BTXA group (P＜0.05).Conclusions The treatment of scar contracture by suitable BTXA injections is safe and effective.