Distribution of HLA-C alleles in Shandong Han population of China
10.3760/cma.j.issn.0254-5101.2013.05.003
- VernacularTitle:HLA-C等位基因在中国山东汉族人群中的分布
- Author:
Chuanfu ZHU
;
Yi ZHANG
;
Yonghong SONG
;
Yan LIU
;
Xiangmin NIE
;
Wenben QIAO
;
Yunlong ZHUANG
- Publication Type:Journal Article
- Keywords:
HLA;
Allele distribution;
Shandong Han population
- From:
Chinese Journal of Microbiology and Immunology
2013;(5):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution of HLA-C alleles in Shandong Han population of China.Methods One hundred and fifty unrelated potential donors,self-claimed as Han population from Shandong province,were selected from China Marrow Donor Program.Genotypes of HLA-C with the donors were identified by PCR-SBT.The frequencies of allele were calculated with direct counting method and the differences with other populations were analyzed with SPSS16.0 x2 software.Results A total of 25 alleles of HLA-C were observed and the most common alleles were C * 06:02 and C * 07:02 with the frequency of more than 10.00％.Moreover,there were 16 kinds of alleles with the frequency of more than 1.00％ accounting for 95.33％ of the total alleles.The distribution of HLA-C alleles in Shandong Han population was similar to that in northern Han population,but had some differences with that in southern Han population.In addition,the distribution of HLA-C alleles in Shandong Han population significantly differed from that of German/African American.Conclusion This study on the distribution of HLA-C alleles in Shandong Han population provides valuable references for further studies on the genetics of HLA,cross-match for organ transplantation and other genetic-associated diseases in this population.
