Influence of injecting prednisolone by inferior turbinate on the serum IL-4 ,IL-5 ,IgE in patients with perennial allergic rhinitis
10.3760/cma.j.issn.1008-6706.2013.13.019
- VernacularTitle:下鼻甲注射泼尼松龙对常年性变应性鼻炎血清IL-4、IL-5、IgE的影响
- Author:
Qiuyan KONG
- Publication Type:Journal Article
- Keywords:
Rhinitis;
allergic;
perennial;
Prednisolone;
Turbinates;
Administration;
intranasal
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(13):1967-1968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the treatment mechanism of inferior turbinate injection of prednisolone on perennial allergic rhinitis(PAR).Methods ELISA and chemiluminescence were used to detect the changes of IL-4,IL-5,IgE in inferior turbinate injection of prednisolone group (treatment group),loratadine group(control group) and healthy group(normal group).Results Compared with the normal group,serum IL-4,IL-5,IgE of 2 groups before treatment were significantly increased (P ＜ 0.01).After treatment,the serum IL-4 level of the treatment group was (62.76 ± 18.21) ng/L,IL-5 level was (24.32 ±9.47) ng/L,IgE level was (112.4 ±57.8) mg/L,compared with before treatment,the differences were statistically significant(P ＜ 0.05).After treatment,IL-4 level of the control group was (140.18 ±25.78) ng/L,IL-5 level was (60.17 ± 17.28) ng/L,IgE level was (186.2 ±55.3) mg/L,compared with before treatment,the differences were not statistically significant(P ＞ 0.05).Conclusions The serum IL-4,IL-5,IgE levels of PAR patients were higher than normal group.Inferior turbinate injection of prednisolone could decrease the IL-4,IL-5,IgE levels and effectively treat PAR.
