Correlation of free fatty acids with carotid artery intima-media thickness in patients with type 2 diabetes
10.3760/cma.j.issn.1671-7368.2013.05.025
- VernacularTitle:2型糖尿病患者游离脂肪酸水平与颈动脉内膜中层厚度的关系
- Author:
Xiujing WANG
;
Jing WANG
;
Yong RUAN
;
Qingying TAN
;
Yun RUAN
- Publication Type:Journal Article
- Keywords:
Carotid artery intima-media thickness;
Insulin resistance;
Free fatty acids
- From:
Chinese Journal of General Practitioners
2013;(5):394-396
- CountryChina
- Language:Chinese
-
Abstract:
Seventy patients with type 2 diabetes (T2DM),23 subjects with impaired glucose tolerance (IGT) and 35 individuals with normal glucose tolerance (NGT) were recruited in the study.Fasting free fatty acids (fFFA) and postprandial free fatty acids (2 hFFA) after oral glucose tolerance test (OGTT) were measured; homeostasis model assessment of insulin resistance (HOMA-IR),area under the curve of free fatty acids (AUCFFA) were calculated.The carotid artery intima-media thickness (IMT) was assessed by color ultrasonography.HOMA-IR,fFFA,2 hFFA,AUCFFA and IMT in T2DM group were 3.3 ±3.2,(0.55 ± 0.20) mmol/L,(0.28 ±0.18)mmol/L,(0.83 ±0.34)mmol · L-1 · h-1 and (0.12±0.05) cm,which were significantly higher than those in NGT group,respectively [1.9 ± 1.3,(0.41 ±0.15) mmol/L,(0.12 ± 0.10) mmol/L,(0.53 ± 0.20) mmol · L-1 · h 1 and (0.09 ± 0.03) cm,all P ＜0.05].Both HOMA-IR and IMT were positively correlated with fFFA,2 hFFA and AUCFFA (all P ＜ 0.05).The results indicate that the levels of fasting and postprantial free fatty acid were related with insulin resistance and atherosclerosis of carotid artery.
