Effects of propofol versus sevoflurane combined with remifentanil anesthesia on activity of nuclear factor kappa B in neutrophil granulocyte during one-lung ventilation in patients undergoing radical resection of esophagus cancer
10.3760/cma.j.issn.0254-1416.2013.04.016
- VernacularTitle:丙泊酚或七氟醚复合瑞芬太尼对食管癌根治术患者单肺通气时中性粒细胞NF-κB活性的影响
- Author:
Libin MA
;
Fanmin MENG
;
Jiaqiang ZHANG
;
Weidong LU
- Publication Type:Journal Article
- Keywords:
Propofol;
Anesthetics,inhalation;
Piperidines;
Respiration,artificial;
NF-kappa B;
Neutrophils
- From:
Chinese Journal of Anesthesiology
2013;(4):451-454
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of propofol versus sevoflurane combined with remifentanil anesthesia on the activity of nuclear factor-kappa B (NF-κB) in neutrophil granulocyte during one-lung ventilation (OLV) in patients undergoing radical resection of esophagus cancer.Methods Forty ASA physical status Ⅰ or Ⅱpatients of both sexes,aged 40-64 yr,with body mass index 18-25 kg/m2,undergoing radical resection of esophagus cancer,were randomized into 2 groups (n =20 each):propofol-remifentanil group (group P) and sevofluraneremifentanil group (group S).Anesthesia was induced with midazolam,sufentanil,etomidate and cisatracurium besylate in both groups.The patients were tracheal intubated and mechanically ventilated.Anesthesia was maintained with iv infusion of propofol 4-8 mg· kg-1 · min-1 in group P,or with inhalation of 1%-3% sevoflurane in group S,and with iv infusion of remifentanil 0.2μg· kg-1 · min-1 and intermittent iv boluses of cisatracurium besylate 7 mg in both groups.The Narcotrend index value was maintained between 40 and 50.Blood samples were taken from the radial artery at 5 min after intubation,the beginning of OLV,30,60 and 90 min of OLV,0 and 10 min after re-expansion of the collapsed lung,and the end of surgery for blood gas analysis and for determination of plasma concentrations of IL-1.The oxygenation index and respiratory index were calculated.The nuclear protein of neutrophil granulocytes was extracted for detection of NF-κB-DNA binding activity.Results Compared with group P,the respiratory index,plasma concentrations of IL-1 and NF-κB-DNA binding activity were significantly increased (P ＜ 0.05),and no significant change was found in the oxygenation index in group S (P ＞ 0.05).Conclusion Compared with sevoflurane-remifentanil anesthesia,propofol-remifentanil anesthesia can inhibit activation of NF-κB in neutrophil granulocyte and is helpful in attenuating the inflammatory response in lung tissues during OLV in patients undergoing radical resection of esophagus cancer.
