Effects of different concentrations of sevoflurane anesthesia on long-term learning and memory abilities in neonatal rats
10.3760/cma.j.issn.0254-1416.2013.02.015
- VernacularTitle:不同浓度七氟醚麻醉对新生大鼠远期学习记忆能力的影响
- Author:
Lai WANG
;
Qingsheng XUE
;
Yan LUO
;
Qingwen ZENG
;
Fujun ZHANG
;
Buwei YU
- Publication Type:Journal Article
- Keywords:
Anesthetics,inhalation;
Infant,newborn;
Cognition disorders
- From:
Chinese Journal of Anesthesiology
2013;(2):191-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different concentrations of sevoflurane anesthesia on longterm learning and memory abilities in neonatal rats.Methods Twenty-seven neonatal Sprague-Dawley rats of both sexes,aged 7 days,weighing 12-20 g,were randomly assigned into 3 groups (n =9 each):control group (C group),2％ sevoflurane group (S1 group) and 3％ sevoflurane group (S2 group).Groups C,S1 and S2 inhaled air,2 ％ sevoflurane and 3 ％ sevofluran for 4 h,respectively.The neonatal rats were reared to 35 days old and underwent open field test,to 36 days old and underwent Morris water maze test,and to 42 days old and underwent continuous multiple-trail inhibition avoidance training.Results Open field test:There was no significant difference in the movement time,movement speed and the time the animals spent in the central square among the 3 groups (P ＞ 0.05).Morris water maze test:Compared with C group,the looking for platform latency on 2nd-5th days in S2 group and on 2nd-3rd days in S1 group was significantly prolonged,and the percentage of time of staying at the platform quadrant was decreased in S1 and S2 groups (P ＜ 0.05 or 0.01).The looking for platform latency on 3rd4th days in S2 group was significantly longer than that in group S1 (P ＜ 0.05).Continuous multiple-trail inhibition avoidance training:The latency detected at 24 h after training was significantly shorter in S1 and S2 groups than in group C (P ＜ 0.05),and in group S2 than in S1 group (P ＜ 0.05).Conclusion Sevoflurane anesthesia decreases the long-term learning and memory function in neonatal rats in a concentration-dependent manner.
