Efficacy of parecoxib sodium for preemptive analgesia: a meta-analysis
10.3760/cma.j.issn.0254-1416.2013.03.003
- VernacularTitle:帕瑞昔布钠超前镇痛的有效性评价:meta分析
- Author:
Minghui CHEN
;
Xiaolong ZHANG
;
Shukun FU
;
Xiaohu YANG
;
Quan LI
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase inhibitors;
Analgesia;
Meta-analysis
- From:
Chinese Journal of Anesthesiology
2013;(3):279-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of parecoxib sodium for preemptive analgesia.Methods PubMed,EMBASE,Cochrane Library,and CNKI database were searched for randomized placebo-controlled trials involving the efficacy of parecoxib sodium for preemptive analgesia.The modified Jadad scale was used for quality assessment.Evaluation indexes included VAS scores at 1,6,12 and 24 h after operation,consumption of morphine within 24 h after operation,and incidences of nausea and vomiting after operation.Meta-analysis was conducted using the Cochrane Collaboration's RevMan 5.0.2 software.Results Fourteen randomized placebo-controlled trials involving 1086 patients were included in our meta-analysis.The modified Jadad scale scores for the 14 studies were ≥ 4.The patients were divided into 2 groups:placebo group and parecoxib sodium 40 mg injected before operation group.The results of meta-analysis showed that VAS scores at 1,6,12 and 24 h after operation were significantly decreased,the consumption of morphine within 24 h after operation was reduced,and the incidences of nausea and vomiting after operation were decreased in parecoxib sodium 40 mg injected before operation group as compared with placebo group (P ＜ 0.05).Conclusion Intravenous injection of parecoxib sodium 40 mg before operation can produce significant preemptive analgesic efficacy and is helpful in decreasing the adverse effect of postoperative analgesia.
