Efficacy analysis of ezetimibe on lipid management in elderly patients with coronary heart disease after coronary intervention
10.3760/cma.j.issn.0254-9026.2013.06.005
- VernacularTitle:依折麦布对老年冠心病患者介入治疗术后血脂管理的疗效分析
- Author:
Mingqin DUAN
;
Gairong HUANG
;
Xianjing XU
;
Xuanchao CAO
;
Yansheng HUANG
- Publication Type:Journal Article
- Keywords:
Antilipemic agents;
Coronary disease;
Angioplasty,transluminal,percutanous coronary
- From:
Chinese Journal of Geriatrics
2013;(6):592-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of ezetimibe combined with atorvastatin calcium on hyperlipidemia,and to evaluate the role of ezetimibe on lipid management in elderly patients with coronary heart disease (CHD) after coronary intervention.Methods A total of 150 elderly CHD patients with hyperlipidemia to undergo coronary intervention in our hospital were selected.Patients were randomly divided into the control group and the experimental group (n=75,each).Patients in control group were treated with atorvastatin,and in the experimental group with ezetimibe plus atorvastatin.The change of blood lipids levels and the incidence of adverse reactions were compared between the two groups 1 month after the treatment.Results The numbers of patients with normal serum levels of total cholesterol (TC),triglycerides (TG),low density lipoprotein (LDLC) were much more in the experimental group than in the control group after treatment [68 cases (90.7％) vs.50 cases (66.7％),62 cases (82.7％) vs.44 cases (58.7％),56 cases (74.7％) vs.38 cases (50.7％),x2 =12.87,10.42,9.23,respectively,all P＜0.01].There was no significant difference in the incidence of adverse reactions between the two groups [5.3％ (4 case) vs.2.7％ (2 cases),x2 =0.17,P ＞ 0.05].Conclusions Compared with atorvastatin calcium treatment,ezetimibe combined with atorvastatin calcium treatment has a better clinical efficacy on hyperlipidemia with no increase of adverse reactions in elderly CHD patients.
