Protective effects of mucosolvan on the respiratory tract in elderly patients with long-time tracheal intubation for upper abdominal operation
10.3760/cma.j.issn.0254-9026.2013.05.016
- VernacularTitle:沐舒坦对长时间气管插管全麻上腹部手术老年人呼吸道的保护作用
- Author:
Wujian DENG
;
Jintai LIN
;
Weijing WU
;
Wenhai XUAN
;
Xianliang LIANG
- Publication Type:Journal Article
- Keywords:
Surgical procedures;
Respiratory tract infection;
Ambroxol
- From:
Chinese Journal of Geriatrics
2013;(5):516-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of mucosolvan on the respiratory tract in elderly patients with long-time tracheal intubation for upper abdominal operation.Methods A total of 88 elderly patients to receive upper abdominal surgery were randomly divided into 2 groups:the treatment group (n=41,treated with antibiotics and mucosolvan 90 mg,iv,bid,for 7 consecutive days) and the control group (n=39,with the same antibiotics but without mucosolvan).Patients indwelling endotracheal tube≤3 hours were excluded.Lung function [forced vital capacity (FVC),forced expiratory volume in 1 second (FEV1),FEV1/FVC ratios (FEV1％)],blood gas analysis (pH,PaCO2,PaO2) and lung condition changes were compared between the two groups before and after surgery.Results There was a significant difference in blood gas analysis between the two groups 3 days after surgery (P＜0.05).There were differences in FEV1 and FEV1％ between the two groups 5 days after surgery (P＜0.05),but no differences were found in FVC in the two groups before versus after surgery.There were significant differences in the incidences of pulmonary infection and atelectasis between the treatment group and the control group [4.9 ％ vs.23.1％ (2 cases vs.9 cases),0％ vs.10.3％ (0 cases vs.4 cases),respectively,both P＜0.05].Conclusions Mucosolvan has a better protective effect on the respiratory tract in elderly patients undergoing upper abdominal surgery and the synergies can be achieved in combination with antibiotics.
