Relationship between insulin resistance and carotid atherosclerosis in elderly patients with type 2 diabetes
10.3760/cma.j.issn.0254-9026.2013.05.012
- VernacularTitle:老年2型糖尿病患者颈动脉粥样硬化与胰岛素抵抗的相关分析
- Author:
Tianqi WANG
;
Zhenhua LI
;
Youshuo LIU
;
Yanghua LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Atherosclerosis;
Insulin resistance
- From:
Chinese Journal of Geriatrics
2013;(5):504-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between insulin resistance and carotid atherosclerosis in elderly patients with type 2 diabetes.Methods A total of 63 elderly patients with type 2 diabetes were divided into 2 groups:group A (HbA1c≤7％,n=30),group B (HbA1c＞7％,n=33); and 30 healthy people were as controls.Fasting blood sugar(FBS),fasting insulin (FINS),glycated hemoglobin (HbA1c) and carotid intima-media thickness (IMT) were measured,atherosclerotic plaques were counted,and insulin resistance was calculated by homeostatic model assessment (HOMA-IR).Results The IMT,number of atherosclerotic plaques and incidence of carotid atherosclerosis were all higher in the two diabetic groups than in controls (P＜0.05).The levels of FINS,HbA1c and HOMA-IR were all higher in group A and group B than in controls (P＜0.05 and P＜0.01),which had a significant difference between group A and group B [(9.7± 2.1)mU/L vs.(13.6±2.0) mU/L; (6.5±0.4)％ vs.(8.2±0.6)％; (3.5±0.4) vs.(6.1±0.5); all P＜0.05].Pearson correlation analysis showed that IMT was positively correlated with FBS and HOMA-IR in group A and group B (r=0.62 and r=0.46,respectively,P＜0.05).Conclusions There is a positive correlation between insulin resistance and carotid atherosclerosis in elderly patients with type 2 diabetes.
