Association between CYP2C19 polymorphisms and efficacy of clopidogrel in coronary atherosclerotic heart disease
10.3760/cma.j.issn.0254-9026.2013.05.006
- VernacularTitle:细胞色素P450氧化酶基因多态性与氯吡格雷治疗冠心病效果的相关性
- Author:
Qin ZHU
;
Xinyu CHEN
;
Guofu WANG
;
Yuandong LV
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Cytochrome P-450 enzyme system;
Polymorphisms,single nucleotide
- From:
Chinese Journal of Geriatrics
2013;(5):483-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between CYP2C19 polymorphisms and efficacy of clopidogrel in Chinese Han patients with coronary atherosclerotic heart disease.Methods A total of 176 Chinese Han patients who underwent percutaneous coronary intervention and were treated with dual antiplatelet therapy with aspirin and clopidogrel were enrolled.Polymorphisms of CYP2C19 * 2,* 3 were measured by PCR-restriction fragment length polymorphism (PCR RFLP).The correlation between the genetic variants and cardiovascular events was analyzed.Results In the 176 patients,the allele frequencies of CYP2C19 * 2 and * 3 were 34.38％ and 5.97％ respectively,the percent of patients with poor metabolizer genotypes (* 2/* 2,* 2/* 3,* 3/* 3) was 14.20％.Among the 176 patients,11 patients reoccured acute coronary syndrome,1 patient suffered from stroke,and 4 patients had stent thrombosis.The incidence of cardiovascular events was 9.09 ％.Thecumulative incidence of cardiovascular events had no significant differences between poor metabolizer genotype carriers and extensive and intermediate metabolizer genotype carriers (16.00％ vs.7.95％,x2 =1.683,P=0.195).Conclusions The frequencies of CYP2C19 poor metabolizer genotypes are higher in Chinese Han population than in Caucasians,but the incidence of cardiovascular events in Chinese Han population is not increased.
