The expression and clinical significance of cyclase-associated protein 2 in hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2013.04.013
- VernacularTitle:腺苷酸环化酶相关蛋白2在肝细胞癌中的表达及意义
- Author:
Jie LIN
;
Bin WANG
;
Aimin HUANG
;
Jingfeng LIU
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Liver cirrhosis;
Cyclase-associated protein 2
- From:
Chinese Journal of Hepatobiliary Surgery
2013;(4):287-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the cyclase-associated protein 2 (CAP2) expression in hepatocellular carcinoma (HCC).Method The expression of CAP2 was determined by reverse transcription PCR,Western blot,and immunohistochemistry in normal liver,cirrhotic liver,and HCC.Results According to reverse transcription PCR and Western Blot,the level of CAP2 was up-regulated in HCC and was further up-regulated in progressed HCC than in early HCC.CAP2 expression was almost absent in normal and cirrhotic liver.The same results were seen in immunohistochemical examination.Also,CAP2 showed stronger expression in medium and poor-differentiated HCC than in well-differentiated HCC.Conclusion CAP2 is an up-regulated gene in HCC and may relate to the stages of hepatocarcinogenesis.Therefore,CAP2 could be used as a valuable molecular marker for HCC diagnosis in the future.
