An analysis on clinical features and prognostic factors of gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2013.05.012
- VernacularTitle:胃肠道间质瘤的临床病理特征与预后的相关性分析
- Author:
Jiehua LI
;
Haitian ZHANG
;
Zhibai CHEN
;
Ka SU
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Pathology,clinical;
Prognosis;
Regression analysis
- From:
Chinese Journal of General Surgery
2013;(5):360-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prognostic factors of gastrointestinal stromal tumors (GIST).Methods A total of 144 GIST patients treated at the First Affiliated Hospital of Guangxi Medical University between January 1996 and December 2011 were analyzed restrospectively.Kaplan-Meier,log-rank test and Cox regression model were used.Results The overall 5-year survival was 59.6％.Log-rank univariate survival analysis showed that the primary location,tumor size,metastasis,operational method,type of tumor cells,invasion of the surrounding organs and tissues,invasion of the smooth muscle,cellularity of the tumor,mitotic counts of the tumor cells,Ki-67 labeling index,P53 expression and targeting therapy were significant prognostic factors (P ＜ 0.05).Cox regression model showed that tumor size,metastasis,operational method,surrounding organs and tissues invasion,cellularity of the tumor,mitotic counts of the tumor cells,P53 and targeting therapy were essential to improve the survival.Conclusions The study suggests that early diagnosis and comprehensive treatment consisting of operation and targeting therapy can significantly improve the survival of GIST.
