The influence of interleukin-2 receptor antagonists exerted on organ transplant recipients

VernacularTitle:白细胞介素2受体拮抗剂对器官移植受体糖代谢的影响
Author: Shunmei HE ; Yao ZHANG ; Xianying CHEN ; Zhaoyang Lü ; Mingxiang YU
Publication Type:Journal Article
Keywords: Interleukin-2 receptor; Antagonists; Organ transplantation; Diabetes mellitus
From: Chinese Journal of Endocrinology and Metabolism 2013;(6):540-543
CountryChina
Language:Chinese
Abstract: [Summary] Interleukin-2 receptor antagonist (IL-2Ra,ie,basiliximab and daclizumab),a new antibody agent,is widely employed in lowering the risk of acute rejection after organ transplantation,but it meanwhile causes increasing concerns on the effect it exerts on glucose metabolism in transplant recipients,and so far the exact effect still remains controversial.New onset diabetes after transplantation (NODAT) is one of the most influential metabolic complications affecting graft survival and patients' long-term outcomes.Some of the current researches indicate that IL2Ra may improve glucose metabolism in the transplant recipients,some show just the opposite,yet others show no effects.Hence further investigations focusing this aspect are needed.