The development and breakthrough of clinical organ transplant tolerance induction
10.3760/cma.j.issn.1007-8118.2013.04.001
- VernacularTitle:临床器官移植免疫耐受诱导的发展和突破
- Author:
Jianke DING
;
Fei PAN
;
Xianliang LI
;
Dazhi CHEN
- Publication Type:Journal Article
- Keywords:
Organ transplant;
Immune tolerance
- From:
Chinese Journal of Hepatobiliary Surgery
2013;(4):243-251
- CountryChina
- Language:Chinese
-
Abstract:
The long-term use of immunosuppressive agents after organ transplantation is associated with many undesirable side effects which may limit the survival of patients and transplanted organs.To patients and transplant surgeons,organ transplantation tolerance is the ultimate goal to improve patient's quality of life.The clinical state of allograft acceptance termed operational tolerance has remained infrequent in clinical transplantation because of the lack of validated assays or biomarkers predictive of tolerance and the concerns about the safety and ethics of complete withdrawal of immunosuppression.Despite these barriers,a number of investigators have continued to conduct well-designed studies with the long-term goal of inducing clinical transplantation tolerance.This review provides an overviewof the currently successful approaches to achieve clinical operational tolerance,including using immunosuppression slow withdrawal in organ transplantation,transplantation tolerance through mixed chimerism and clinical application of T regulatory cells in tolerance.
