Correlation analysis of lower respiratory tract fungal infection in hospital of Zhoushan archipelago area
10.3760/cma.j.issn.1000-6680.2013.05.010
- VernacularTitle:舟山海岛地区医院内下呼吸道真菌感染及相关因素分析
- Author:
Xianjun DING
;
Qiongna CHEN
;
Wangyu ZHU
;
Qilong LIN
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Pneumonia,bacterial;
Lung diseases,fungal;
Cross infection;
Candida albicans;
Amphotericin B;
Flucytosine
- From:
Chinese Journal of Infectious Diseases
2013;(5):299-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the microbial strains,risk factors and resistance profiles of lower respiratory tract fungal infection in hospital of Zhoushan archipelago area.Methods A total of 204 patients who were hospitalized for lower respiratory tract infection were retrospectively analyzed from May 2008 to April 2011 in Zhoushan archipelago area,and collected 204 fungal strains isolated from confirmed lower respiratory tract fungal infection cases.Chi-square test and Logistic regression analysis were performed.Results Among the 204 fungal strains isolated from lower respiratory tract specimens,110 (53.8％) strains of Candidaalbicans,32 (15.7％) strains of Candida tropicalis,24 (11.8％) strains of Candida glabrata,12 (5.9％) strains of Candida krusei,14 (6.9％) strains of other Candida,and 12 (5.9％) strains of Aspergillus were detected.Logistic regression analysis showed that chronic obstructive pulmonary disease,bacterial pneumonia,long-term use of broadspectrum antibiotics and corticosteroids,endotracheal intubation or incision,old age,exposure in intensive care unit (ICU),and hospitalization ≥7 days were major risk factors (P=0.000,0.001,0.000,0.000,0.012,0.000,0.000,0.000).The resistance rates of isolated Candida against amphotericin B,5-flucytosine,voriconazole,itraconazole and fluconazole were 0,2.1％,4.2％,14.8％ and 22.9％,respectively.Conclusions Candida albicans is the major pathogen of lower respiratory tract fungal infection in hospital of Zhoushan archipelago area,and Candida is sensitive to amphotericin B,5-flucytosine and voriconazole.
