Study on clinical efficacy and endothelial function protection of Tianma Gouteng Granule in interfering primary hypertension patients with hyperactivity of liver-yang
10.3760/cma.j.issn.1008-1372.2013.06.007
- VernacularTitle:天麻钩藤颗粒治疗肝阳上亢型原发性高血压患者的临床疗效及对血管内皮功能的影响
- Author:
Zhijie SHEN
;
Ying ZHANG
;
Yingjie WANG
;
Xiaolong WANG
- Publication Type:Journal Article
- Keywords:
TIANMA GOUTENG DRINK/therapeutic use;
TIANMA GOUTENG DRINK/administration & dosage;
Hypertension/ZHONG YAO LIAO FA;
LIVER-YANG HYPERACTIVITY/ZHONG YAO LIAO FA;
Endothelium,vascular/drug effects
- From:
Journal of Chinese Physician
2013;(6):744-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical anti-hypertension effect,clinical traditional Chinese medicine (TCM) syndrome improvement and endothelium function such as cardio-ankle vascular index (CAVI),flow-mediated dilatation (FMD) and endothelial micro-particle (EMP) protection of Tianma Gouteng Granule in interfering primary hypertension patients with hyperactivity of liver-yang.Methods Sixty six primary hypertension patients with hyperactivity of liver-yang were randomly divided into the control group (standardized treatment,n =35) and the treatment group (Tianma Gouteng Granule + standardized treatment,n =31) according to the random number method.In four weeks' follow-up treatment,the changes in clinical efficiency,TCM syndrome improvement,CAVI,FMD and EMP were observed.Results (1)Total clinical efficiency ratio was 71.43％ in control vs.70.97％ in treatment without statistical significance (P ＞0.05).(2) TCM syndrome improvement was better in treatment group than that in control group (93.55％ vs 74.29％,x2 =4.39,P ＜ 0.05),especially in improving symptoms such as dissiness,headache,dysphoria in chest,palms and soles,insomia and tinnitus (P ＜ 0.05).(3) In the aspect of endothelium protection,treatment group can greatly improve CAVI compared with control (L-CAVI ∶ t =2.11,P ＜0.05;R-CAVI∶ t =2.15,P ＜0.05) ; the levels of FMD(t =-4.65,P ＜0.01) and EMP (t =4.35,P ＜ 0.01)were significantly improved after treatment (P ＜ 0.05) while no statistical meaning was found between two group.Conclusions Tianma Gouteng Granule can improve TCM syndrome,decrease CAVI level.FMD and EMP were significantly decreased in treatment group.Multi-factor regression analysis showed that EMP level was related to pulse pressure.
