Relationship between serum hepatitis B virus covalently closed circle DNA and clinical stage as well as pathological grade of chronic hepatitis B in children
10.3760/cma.j.issn.1673-4912.2013.03.017
- VernacularTitle:儿童乙型肝炎血清乙型肝炎病毒共价闭合环状DNA与临床和病理分级分期的关系
- Author:
Xiaoyan LEI
;
Yonghong SUN
;
Julan YANG
;
Hong YUAN
;
Huiling JIANG
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis;
Covalently closed circle DNA;
Children
- From:
Chinese Pediatric Emergency Medicine
2013;20(3):292-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum hepatitis B virus covalently closed circle DNA (HBV cccDNA) as well as liver function and liver tissue pathological changes in children with chronic hepatitis B.Methods One hundred and twenty-four HBV-DNA positive children with hepatitis B were enrolled.Among 124 patients,65 cases were HBV carriers,59 cases were chronic hepatitis (mild in 31 cases,moderate in 18 cases and severe in 10 cases).HBV cccDNA in serum and liver function were detected,46 of which underwent liver biopsy and liver tissue inflammation and fibrosis grading classification was made.Results In moderate and severe cases,positive rates of serum HBV cccDNA (77.8％,100％) were higher than those of the HBV carriers and mild cases (32.3％,54.8％) (x2 =25.429,P ＜ 0.01),indicating more severe illness in children,detection rate of serum HBV cccDNA was higher.ALT,AST,and TBIL were higher in serum HBV cccDNA positive group than those of negative group[(95.6 ± 18.2) U/L vs (52.5 ± 17.7) U/L,(88.8 ±20.3) U/L vs (48.4 ±21.4) U/L,(68.4 ±24.6) μmol/L vs (28.3 ± 23.9) μmol/L](t =15.572,10.750,17.067,P ＜ 0.01).Serum HBV cccDNA and liver inflammatory activity and fibrosis showed no significant correlationship.Conclusion Serum HBV cccDNA is a sensitive indicator of viral replication,the more severe the disease situation,the peripheral HBV cccDNA detection rate is higher.But it is not entirely consistent with liver inflammation and fibrosis,so it can not completely reflect the degree of liver damage.
