Preventive effect of nano-powder of Wugong-sanqi on postoperative intestinal adhesion of rats

VernacularTitle:蜈蚣三七纳米粉对大鼠术后肠黏连的预防作用
Author: Xin HUANG ; Yiming LI ; Fuqin XU ; Mingqian HE ; Ziting QIU ; Feihong BING
Publication Type:Journal Article
Keywords: Nano-powder of Wugong-sanqi; Intestinal adhesion; Rats
From: International Journal of Traditional Chinese Medicine 2013;(6):513-515
CountryChina
Language:Chinese
Abstract: Objective To investigate the preventive effect of nano-powder of Wugong-sanqi (NW),the rhizome of Anemone flaccid,on postoperative intestinal adhesion in rats.Methods Fifty SD rats were subjected to operation with Ellis' method for establishing intestinal adhesion models,then randomly divided into 5 groups (n=10),namely model,positive (Dexamethasone,i.m.10 mg/kg),NW high,medium and low dose group (p.o.450,225 and 112 mg/kg,respectively).Another ten normal rats were selected as normal control group.After administration 3 days pre-operation and 7 days post-operation,all of rats were killed,the intestinal adhesion was graded and the tissues were observed by optical microscope.Results NW evidently reduced the severity of postoperative adhesion (P＜0.05 or P＜0.01),compared with model group.The histopathologic changes such as proliferation of fibroblast cells and capillary,interstitial granulomas and inflammatory cells infiltration in intestinal tissues were also improved significantly in NW groups.Conclusion NW could inhibit the formation of postoperative intestinal adhesion effectively.