Function of AFP and DCP in evaluating the prognosis of hepatocarcinoma
10.3760/cma.j.issn.1673-4203.2013.04.006
- VernacularTitle:AFP和DCP在肝癌患者预后评价中的作用
- Author:
Jijun CHEN
;
Hongxun YANG
;
Chao LI
;
Binggang ZHAO
;
Qiang HAN
;
Peng ZHAO
;
Wen YIN
- Publication Type:Journal Article
- Keywords:
Hepatocarcinoma;
Fetoprotein;
Carboxy prothrombin;
Prognosis
- From:
International Journal of Surgery
2013;(4):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis in patients with hepatocarcinoma by examining the expression of α-fetoprotein (AFP) and des γ prothrombin (DCP).Methods Retrospectively analyzed the expression of AFP and DCP in 105 patients received curative hepatectomy.Divided the patients into three groups as follow:the tumor markers were both negative pre-and post-operation (Group N) ; the tumor markers decreased to normal after operation (Group D) ; the tumor markers kept positive or decreased but still higher positive after operation (Group P).Then combined the two markers and divided the patients into 4 groups:two markers both negative(AFP + DCP +)(Group A) ; AFP + DCP-(Group B) ; AFP-DCP + (Group C) ; AFP-DCP-(Group D).Results High AFP and DCP levels were significantly associated with poor tumor-free and overall survival.The presence of large size and advanced stage were significantly associated with Group P.Overall survival in the AFP-N group was significantly better than that of other groups and overall survival in DCP-N group were significantly better than that of the P group.After the combination,Group A had the best overall and tumor free survival rate while the D group had the worst.The differences between B and C group were not significant.Conclusions AFP and DCP can be both used solely as tumor markers and the expressions of them are associated with the prognosis.The combination of two markers can be used for better prediction of hepatocarcinoma.
