Research on epidermal growth factor receptor in breast cancer
10.3760/cma.j.issn.1673-4203.2013.03.013
- VernacularTitle:表皮生长因子受体在乳腺癌中的研究进展
- Author:
Lihua ZHENG
;
Miao CAO
;
Xueliang WANG
;
Zhao XU
;
Liang ZHANG
;
Yunjiang LIU
- Publication Type:Journal Article
- Keywords:
Receptor epidermal growth factor;
Breast neoplasms;
Carcinoma
- From:
International Journal of Surgery
2013;(3):188-190
- CountryChina
- Language:Chinese
-
Abstract:
Decades researches of molecular oncology have found some moleculars which can promote tumor growth and help cancer surrive.This brings new hope for the treatment of tumors.Epidermal growth factor receptor (EGFR) is the first important molecular to inhibit tumor growth.Fifty percent triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC) overexpress EGFR.EGFR and its downstream pathway can regulate epithelial-mesenchymal transition,promote tumor cell migration.EGFR therapy can improve the chemosensitivity of TNBC cells,apoptotic signal transduction occur.These studies suggest that the EGFR targeted therapy may have an important role in the treatment of TNBC and IBC.
