Effect of diammonium glycyrrhizinate and astragalus membranaceus injection on the comprehensive score of acute lung injury
10.3969/j.issn.1008-9691.2013.04.009
- VernacularTitle:甘草酸二铵与黄芪注射液治疗急性肺损伤疗效分析
- Author:
Zheng LI
;
Hua HUANG
;
Fengkun CHEN
;
Kegang HUANG
;
Yaoyuan LIANG
;
Wenyan QIU
;
Shuai CHEN
;
Yuji LIANG
- Publication Type:Journal Article
- Keywords:
Diammonium glycyrrhizinate;
Astragalus membranaceus injection;
Acute lung injury;
Acute respiratory distress syndrome;
Lung injury score;
Acute physiology and chronic health evaluationⅡscore;
Systemic inflammatory response syndrome score
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2013;(4):213-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of diammonium glycyrrhizinate(DG) and astragalus membranaceus (AM) injection on the clinical comprehensive score in patients with acute lung injury (ALI). Methods According to the random number table method,a prospective random controlled study was conducted in which 60 cases of patients with ALI were divided into a study group and a control group(each,30 cases). Both groups received a comprehensive treatment based on the new guidelines,and the study group was additionally given DG and AM injection(DG 150 mg+AM 20 ml)one time per day for 7 days. The scores of lung injury,acute physiology and chronic health evaluationⅡ(APACHEⅡ)and systemic inflammatory response syndrome(SIRS)were measured at baseline,3rd and 7th day after treatment,and ventilation support time and final disease mortality rate were also calculated in all the patients. Results There were no statistically significant differences between the two groups in the scores of lung injury,APACHEⅡand SIRS before treatment and after treatment for 3 days(all P>0.05),with prolonged treatment,the above indexes were significantly reduced compared with those before treatment in the two groups,and the decreases in scores of indexes in study group was more significant than those in control group after treatment(lung injury score:1.31±0.99 vs. 2.29±1.08,APACHEⅡscore:18.43±8.17 vs. 24.23±6.98,SIRS score:1.69±0.89 vs. 2.60±1.04,all P<0.01). The time(hour)for ventilator support in study group was shorter than that in the control group(176.10±57.81 vs. 286.07 ± 156.27,P<0.01),but there was no statistically significant difference in mortality rate between the two groups(13.33%vs.16.67%,P>0.05). Conclusion The results suggest that DG and AM injection improve the scores of lung injury,APACHEⅡand SIRS,and alleviate the lung injury,so that the injection is beneficial to the early weaning from the ventilator to support treatment in patients with acute lung injury,and has certain therapeutic effect on ALI.
