The relationship between serum HBeAg、HBV DNA and liver pathological change in chronic hepatitis B virus carriers with normal liver function
10.3760/cma.j.issn.1008-6315.2012.13.010
- VernacularTitle:肝功能正常的慢性乙型肝炎病毒感染者病毒复制标志物与肝组织病理改变的关系
- Author:
Shixiang CHEN
;
Ping FAN
;
Weixin HE
;
Jun JIANG
;
Zhiyuan XIONG
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
HBeAg
- From:
Clinical Medicine of China
2012;(z1):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum HBeAg、the qualification of HBV DNA and the liver pathologic change in chronic hepatitis B virus (HBV)carriers with normal liver function.Methods Two hundred and forty-four chronic hepatitis B virus carriers with normal liver function were performed pathology examination by Liver biopsy.Meanwhile liver function,HBV DNA level and serological serum markers of B-hepatitis examination were detected.Results Pathology results showed that,of all 244 cases,7 cases was cirrhosis(2.9％),143 for slight CHB (58.6％),32 for moderate CHB (13.1％) and 9 for severe CHB (3.6 ％).And 53 (21.7％)chronic hepatitis B virus carriers were the normal histology morphology.Fony-eight cases (19.7％) were in inflammation stage G≥2 and 54(22.1％) were with fibrosis stage S≥2.For cases with HBV DNA positive,The inflammation and ftbrosis stages in HBeAg negative group were more severe than that in HBeAg positive group (P ＜ 0.05).The fibrosis stages in patients with low HBV DNA level were severe than that in high HBV DNA levels (P ＜ 0.05).No significant differences were observed in the inflammation stage between subjects with high or low HBV DNA level.Conclusion Most chronic HBV carriers with normal liver function were with different degrees of liver inflammation and fibrosis.HBeAg and HBV DNA associated with liver pathological change.
