Celecoxib combined with tamoxifen prevents methylnitrosourea-in-duced breast tumor in rats

VernacularTitle:塞来昔布联合三苯氧胺对甲基亚硝基脲诱导大鼠乳腺肿瘤的影响*
Author: Danxian JIANG ; Hua WU ; Caixia LIANG ; Lijun MAO ; Xionghui MA ; Yinggui HUANG
Publication Type:Journal Article
Keywords: breast tumor; chemoprevention; cyclooxygenase 2; celecoxib; tamoxifen
From: Chinese Journal of Clinical Oncology 2013;(14):824-827
CountryChina
Language:Chinese
Abstract: Objective:The present study aims to evaluate the chemopreventive effect of celecoxib combined with tamoxifen on breast tumor induced by methylnitrosourea (MNU) in rats. Methods:A total of 140 SD female rats were injected with MNU to estab-lish breast tumor models. The rats were divided subsequently into control, celecoxib, tamoxifen, and combination groups. The occur-rence rates, volumes of breast tumor, and expression levels of cyclooxygenase 2 (COX-2) and c-erbB-2 were observed. Results:The tu-mor occurrence rates were lower in the celecoxib and tamoxifen groups than in the control group. The combination group exhibited the lowest tumor-occurrence rate. The tumor volumes of the celecoxib and tamoxifen groups were lower than that of the control group. The combination group had the least tumor volume. The positive rates of COX-2 and c-erbB-2 in the celecoxib and combination groups were lower than those in the control and tamoxifen groups (P<0.05). Conclusion:The combination of celecoxib and tamoxifen can sig-nificantly suppress MNU-induced breast tumor in female rats.