Relationship of D-dimer with the prognosis of non-Hodgkin's lymphoma

VernacularTitle:D-二聚体水平与非霍奇金淋巴瘤患者预后关系的研究
Author: Wenhua JIANG ; Jun GAO ; Pengfei LIU
Publication Type:Journal Article
Keywords: D-dimer; non-Hodgkin's lymphoma; prognosis
From: Chinese Journal of Clinical Oncology 2013;(14):838-841
CountryChina
Language:Chinese
Abstract: Objective:Increased D-dimer level has been recently correlated with the progression and high mortality rate of some cancers. This study aimed to determine whether the plasma D-dimer level was a predictor of non-Hodgkin lymphoma (NHL). Methods:Clinical data of 425 with NHL were retrospectively reviewed. Variables such as clinicopathological factors, plasma D-dimer levels, and the international prognostic index (IPI) were evaluated. Results: The plasma D-dimer level was closely correlated with the IPI. The overall 1-, 3-, and 5-year survival rates of the low plasma D-dimer levels were 80%, 75%, and 50%;those for the high plasma D-dimer levels were 41%, 33%, and 9%, respectively (P<0.001). Compared with an IPI of zero or one, IPI values≥4 were predictive of poor prognosis (P<0.001). The Ann Arbor stage, pathological classification, plasma D-dimer level, and IPI were found to be significantly as-sociated with mortality. However, similar to IPI, the plasma D-dimer level was the independent risk factor affecting multivariate analy-sis. Conclusion:High D-dimer levels are a potential prognostic marker for NHL.