Advances in detection of circulating tumor cells in non-small cell lung cancer
10.3969/j.issn.1000-8179.2013.14.013
- VernacularTitle:非小细胞肺癌循环肿瘤细胞检测进展*
- Author:
Peng CHEN
;
Lei LI
- Publication Type:Journal Article
- Keywords:
circulating tumor cells;
non-small cell lung cancer;
detection;
chemotherapy
- From:
Chinese Journal of Clinical Oncology
2013;(14):862-865
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the most common cancer worldwide, accounting for approximately 18%of all cancer-related deaths. Circulating tumor cells (CTCs) have the capacity to spread into the blood stream. This capacity of CTCs is one of the most critical fac-tors for unfavorable clinical outcome of patients with NSCLC. Detection of CTCs using a simple blood test may assist in early detec-tion of lung cancer. Researchers have attempted to isolate CTCs from peripheral blood using various techniques. Although reports on CTC detection are abundant, methodological aspects concerning sensitivity, specificity, and reproducibility have prevented a clear ap-praisal of the clinical impact. This paper gives a brief description of each CTC detection method.
