Clinical efficacy of reduced glutathione in the treatment of drug-induced liver injury of elder

VernacularTitle:还原型谷胱甘肽治疗老年人药物性肝损害38例效果观察
Author: Yihong ZHANG ; Pingjing MING ; Wei YU
Publication Type:Journal Article
Keywords: Reduced glutathione; Drug liver injury; Elder
From: Clinical Medicine of China 2012;(z1):16-18
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical efficacy of reduced glutathione in the treatment of druginduced liver injury of elder.Methods Seventy-two cases of diagnosed drug-induced liver injury were randomly divided into regular treatment group (n =34) and reduced glutathione treatment group (n =38).Both groups were given conventional liver protection therapy including energy mixture,diammonium glycyrrhizinate and potassium magnesium aspartate.Patients with the reduced glutathione treatment group were additionally treated with reduced glutathione 1.8 g,iv for 4 weeks.Results The total effective rate were 84.2％ for reduced glutathione treatment group and 61.8％ for regular treatment group.There was significant difference between two groups (x2 =4.6541,P ＜ 0.05).Conclusion Reduced glutathione can significantly improve drug-induced liver injury of the elder.